The invention of alkaline phosphatase as a health relevant enzyme
Poelstra, K., Bakker, W.W., Klok, P.A., Kamps, J.A., Hardonk, M.J. and Meijer, D.K., 1997. Dephosphorylation of endotoxin by alkaline phosphatase in vivo. The American journal of pathology, 151(4), p.1163.
Patient studies with RESCAP: Possible therapeutic strategies
Kats, S., Schönberger, J.P., Brands, R., Seinen, W. and van Oeveren, W., 2011. Endotoxin release in cardiac surgery with cardiopulmonary bypass: pathophysiology and possible therapeutic strategies. An update. European journal of cardio-thoracic surgery, 39(4), pp.451-458.
Patient studies with RESCAP: Safety and efficacy data
Keizer, H., Kats, S., Christis, I., Heylen, R., Oosting, R., Seinen, W. and Brands, R., Safety and efficacy data of a randomized, double-blind, placebo-controlled phase II study with the biological response modifier “bRESCAP” in patients undergoing cardiac surgery (APPIRED II).
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Kaliannan, K., Hamarneh, S.R., Economopoulos, K.P., Nasrin Alam, S., Moaven, O., Patel, P., Malo, N.S., Ray, M., Abtahi, S.M., Muhammad, N. and Raychowdhury, A., 2013. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proceedings of the National Academy of Sciences, 110(17), pp.7003-7008.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Kühn, F., Adiliaghdam, F., Cavallaro, P.M., Hamarneh, S.R., Tsurumi, A., Hoda, R.S., Munoz, A.R., Dhole, Y., Ramirez, J.M., Liu, E. and Vasan, R., 2020. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. JCI insight, 5(6).
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Pickkers, P., Heemskerk, S., Schouten, J., Laterre, P.F., Vincent, J.L., Beishuizen, A., Jorens, P.G., Spapen, H., Bulitta, M., Peters, W.H. and van der Hoeven, J.G., 2012. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Critical care, 16, pp.1-12.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Davidson, J.A., Khailova, L., Treece, A., Robison, J., Soranno, D.E., Jaggers, J., Ing, R.J., Lawson, S. and Lujan, S.O., 2019. Alkaline phosphatase treatment of acute kidney injury in an infant piglet model of cardiopulmonary bypass with deep hypothermic circulatory arrest. Scientific reports, 9(1), p.14175.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Heemskerk, S., Masereeuw, R., Moesker, O., Bouw, M.P., van der Hoeven, J.G., Peters, W.H., Russel, F.G., Pickkers, P. and APSEP Study Group, 2009. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Critical care medicine, 37(2), pp.417-e1.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Santos, G.M., Ismael, S., Morais, J., Araújo, J.R., Faria, A., Calhau, C. and Marques, C., 2022. Intestinal alkaline phosphatase: A review of this enzyme role in the intestinal barrier function. Microorganisms, 10(4), p.746.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Adiliaghdam, F., Cavallaro, P., Mohad, V., Almpani, M., Kühn, F., Gharedaghi, M.H., Najibi, M., Rahme, L.G. and Hodin, R.A., 2020. Targeting the gut to prevent sepsis from a cutaneous burn. JCI insight, 5(19).
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Kahrovic, A., Poschner, T., Schober, A., Angleitner, P., Alajbegovic, L., Andreas, M., Hutschala, D., Brands, R., Laufer, G., & Wiedemann, D. 2023. “Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis.” Int. J. Mol. Sci. 24(14): 11728.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Presbitero, A, E.Mancini, R.Brands, V.Krzhizhanovskaya, P. Sloot, Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence Front. Immunol., 11 October 2018.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Anne-Kristin Schaefer, Doris Hutschala, Martin Andreas, Martin Bernardi, Ruud Brands, Shiva Shabanian, Günther Laufer, Dominik Wiedemann. Decrease in serum alkaline phosphatase and prognostic relevance in adult cardiopulmonary bypass. Interactive CardioVascular and Thoracic Surgery (2020) 1–8.
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Supportive literature on the potential of RESCAP® (alkaline phosphatase)
Vu T, Fricke TA, Smith JA. A Review of Alkaline Phosphatase in Preventing Systemic Inflammation after Cardiac Surgery. European Journal of Respiratory Medicine. 2021; 3:2.
CFO
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www.alloksys.com Wageningen, the Netherlands, 24 August 2023 – Alloksys Life Sciences, a clinical stage biotech company specializing in the development of critical care medicines, today
Alloksys’s RESCAP® platform therapeutic compound will be applied in patients that suffer from severe burn trauma. RESCAP® administration is expected to significantly attenuate the overall
APPIRED III study is getting well on its way with 9 centres started with including patients. These centres are Singapore NUH, CZE Eindhoven, Jessa, Hasselt,
Computational model clarifies immune response during cardiac surgery 11 October 2018 A research team led by Peter Sloot, professor of Complex Adaptive Systems at the
After approval was obtained in October 2018, the kidney transplantation study with RESCAP® platform technology under supervision of PI Dr Joost van der Heijden from
AMRIF, Alloksys’s sister company is readying up for trials in several chronic inflammatory disease applications. Among these diseases are unmet medical need applications in Neurodegenerative
Following the start of patient inclusion in Europe, the first Asian center participating international study APPIRED lll has started patient recruitment. The National University Heart
Alloksys Life Sciences is a pioneering company in the field of alkaline phosphatase-based medical treatments for critical care patients.
